Katherine Kramer

OU Major: 
Biomedical Engineering
Research Mentor: 
Chung-Hao Lee
Describe your undergraduate research or creative project: 
The mitral valve (MV) and the tricuspid valve (TV) are comprised of four morphologically distinct tissue layers as determined by the microstructural components, such as collagen and elastin. The objective of this study is to delineate the relationship between the mechanics and morphology of each individual layer of the anterior leaflets (AL). Microdissection of the MVAL yielded three layers: Atrialis/Spongiosa, Fibrosa, and Ventricularis; the TVAL yielded two layers: Atrialis/Spongiosa and Fibrosa/Ventricularis. The mechanical properties of each layer were elucidated using biaxial mechanical testing with multiple loading protocols that mimic various physiological loads. Dissected specimens were fixed in formaldehyde for histology analysis to identify collagen distribution in MVAL and TVAL tissue layers. Our biaxial mechanical testing results have indicated that the individual layers exhibit nonlinear anisotropic mechanical responses. Histological analysis has shown the fibrosa layer...
Awards and/or presentations: 
Kramer, Katherine. "Layer-specific mechanical responses and morphological structure of atrioventricular valve leaflets." Curiosity to Creativity Spring Symposium, 25 April 2018, Oklahoma Memorial Union, Norman, OK